Can you turn off the chatter during a campaign?
Sure, but you have to manually edit each mission file before you fly it. It was planned in the past at one point to have pre-set Radio Silence options for Dgen, but it never came to be.
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"My dear brothers, take note of this: Everyone should be quick to listen, slow to speak and slow to become angry, for man's anger does not bring about the righteous life that God desires."
-James 1:19-20