I read the readme file and it seems that its strictly a multiplayer patch.

SP fixes:

1. Fixed the bug with shooting from the grenade launcher. The grenade is fired with the first shot now.
2. Fixed the disappearing weapons when crouching for a long time.
3. Fixed the game crash on Pripyat location, when the player approached any of the monolithians' camps.
4. Fixed Voronin's tasks to eliminate the bandit Poker.
5. Fixed the random quests at the Wild Territory.
6. Fixed the random task to destroy the bandits' camp at the Cordon.
7. Fixed the random Barkeep's task to clear the snorks lair at the Dark Valley.
8. Fixed the bug with the automatic task to defend the camp when switching location or saving/loading the game.
9. Fixed the random quest to destroy the mutants lair when pseudo dogs are nearby.
10. Fixed the task to destroy the mutants lair.
11. Fixed the random tasks with the raids of characters' camps.
12. Fixed the choice of goods at Barkeep and Petrenko after completing the random tasks.
13. The wounded do not run away from the grenade now.
14. The zombies at Yantar do not run from the grenade now.
15. Fixed the crash caused by the patrol route at Yantar.
16. Fixed the crash caused by the patrol route at Agroprom Research Institute.
17. Fixed the task with getting rid of the Duty group in the village at the Military Warehouses level.
18. Fixed the bug with repeating the scene of the Duty group ambush at the beginning of the Military Warehouses level.
19. Fixed the bug with camera fly-through on the stadium at Pripyat.
20. Fixed the bug with Bes character, when the latter couldn't be healed.